Anticorps Recombinant de lapin anti-UFM1

UFM1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242505E9

N° de cat : 85068-5-PBS

Synonymes

Ubiquitin-fold modifier 1, ubiquitin fold modifier 1, C13orf20, BM-002, BM 002

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Galerie de données de validation

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  WB analysis using 85068-5-RR (same clone as 85068-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85068-5-RR (UFM1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85068-5-PBS in a different storage buffer formulation.

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Informations sur le produit

85068-5-PBS cible UFM1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: UFM1 Protéine recombinante Ag8667
• Nom complet: ubiquitin-fold modifier 1
• Masse moléculaire calculée: 85 aa, 9 kDa
• Poids moléculaire observé: 9-12 kDa
• Numéro d’acquisition GenBank: BC005193
• Symbole du gène: UFM1
• Identification du gène (NCBI): 51569
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

UFM1 (Ubiquitin-fold modifier 1) is a ubiquitin-like protein covalently conjugated with intracellular proteins through UFMylation (modification by UFM1), a process similar to ubiquitylation (PMID: 38141606). UFM1 is conjugated to its target proteins by E1-like activating enzyme UBE1DC1 and E2-like conjugating enzyme UFC1 in a manner analogous to ubiquitylation (PMID: 28234446; 33066455). At the molecular level, UFMylation is an important mediator of the protein function. Dysregulation of the UFM1 system, e.g., the knockout of UFMylation components, disturbs proteome homeostasis and triggers endoplasmic reticulum stress. Such changes are linked to developmental disorders, tumorigenesis, tissue injury, inflammation, and several hereditary neurological syndromes (PMID: 36932998).

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