Anticorps Polyclonal de lapin anti-Ubiquilin 1

Ubiquilin 1 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 22126-1-PBS

Synonymes

UBQLN1, PLIC 1, hPLIC-1, hPLIC1, hPLIC 1

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Galerie de données de validation

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  WB analysis using 22126-1-AP (same clone as 22126-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 22126-1-AP (Ubiquilin 1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22126-1-PBS in a different storage buffer formulation.

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  WB analysis of Transfected HEK-293 using 22126-1-AP (same clone as 22126-1-PBS)

  Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 22126-1-AP (Ubiquilin 1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22126-1-PBS in a different storage buffer formulation.

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  IF Staining of HeLa using 22126-1-AP (same clone as 22126-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using Ubiquilin 1 antibody (22126-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 22126-1-PBS in a different storage buffer formulation.

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Informations sur le produit

22126-1-PBS cible Ubiquilin 1 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Ubiquilin 1 Protéine recombinante Ag17530
• Nom complet: ubiquilin 1
• Masse moléculaire calculée: 589 aa, 63 kDa
• Poids moléculaire observé: 63-71 kDa
• Numéro d’acquisition GenBank: BC010066
• Symbole du gène: Ubiquilin 1
• Identification du gène (NCBI): 29979
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

UBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP (PMID: 21852239). This antibody detects 70kD band of UBQLN1.

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