Anticorps Recombinant de lapin anti-VAT1

VAT1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251841D6

N° de cat : 86847-1-PBS

Synonymes

EC:1.-.-.-, Synaptic vesicle membrane protein VAT-1 homolog, VATI

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Galerie de données de validation

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  WB analysis using 86847-1-RR (same clone as 86847-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86847-1-RR (VAT1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86847-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 86847-1-RR (same clone as 86847-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86847-1-RR (VAT1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86847-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86847-1-PBS cible VAT1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: VAT1 Protéine recombinante Ag16652
• Nom complet: vesicle amine transport protein 1 homolog (T. californica)
• Masse moléculaire calculée: 42 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC015041
• Symbole du gène: VAT1
• Identification du gène (NCBI): 10493
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Vesicle amine transport protein 1 (VAT1) is expressed in neurons and neuroendocrine cells, where it participates in vesicular monoamine uptake and in the docking/fusion steps of neurotransmitter release. Beyond the nervous system, VAT1 binds anionic phospholipids (phosphatidic acid and phosphatidylserine) and catalyses their inter-membrane transfer, thereby integrating lipid metabolism with vesicle trafficking. Recent tumour-biology studies have revealed that VAT1 is frequently up-regulated in aggressive gliomas and gastric cancers; its abundance correlates with enhanced cell migration, radioresistance and an immunosuppressive micro-environment. (PMID: 39832459,PMID: 31524269)

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