Anticorps Monoclonal anti-VDR

VDR Monoclonal Antibody for ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

, ELISA

Conjugaison

Non conjugué

CloneNo.

4B8G3

N° de cat : 60116-1-Ig

Synonymes

VDR

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Galerie de données de validation

• 

  WB analysis of HeLa using 60116-1-Ig

  HeLa cells were subjected to SDS PAGE followed by western blot with 60116-1-Ig (VDR antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

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Applications testées

Dilution recommandée

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

60116-1-Ig cible VDR dans les applications de , ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: VDR Protéine recombinante Ag6012
• Nom complet: vitamin D (1,25- dihydroxyvitamin D3) receptor
• Masse moléculaire calculée: 48 kDa
• Numéro d’acquisition GenBank: BC060832
• Symbole du gène: VDR
• Identification du gène (NCBI): 7421
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

The vitamin D receptor (VDR), also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. This antibody is a mouse monoclonal IgG1 antibody to human VDR.