Anticorps Monoclonal anti-VDR

• Phare
• Validé par KD/KO

VDR Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1A9C1

N° de cat : 67192-1-PBS

Synonymes

NR1I1, VDR, Vitamin D3 receptor

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Galerie de données de validation

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  WB analysis using 67192-1-Ig (same clone as 67192-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 67192-1-Ig (same clone as 67192-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 67192-1-Ig (same clone as 67192-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 67192-1-Ig (same clone as 67192-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 67192-1-Ig (VDR antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67192-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67192-1-PBS cible VDR dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: VDR Protéine recombinante Ag28188
• Nom complet: vitamin D (1,25- dihydroxyvitamin D3) receptor
• Masse moléculaire calculée: 48 kDa
• Poids moléculaire observé: 48-55 kDa
• Numéro d’acquisition GenBank: BC060832
• Symbole du gène: VDR
• Identification du gène (NCBI): 7421
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The vitamin D receptor (VDR), also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. The VDR exists two isoform with the MV 48 kDa and 54 kDa.

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