Anticorps Recombinant de lapin anti-VE-cadherin/CD144

VE-cadherin/CD144 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241953D4

N° de cat : 98251-1-RR

Synonymes

VE-cadherin, VE Cad, Cdh5, Cd144, cadherin 5

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Galerie de données de validation

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  FC experiment of bEnd.3 using 98251-1-RR

  1x10^6 bEnd.3 cells (left) or C2C12 (right) were surface stained with 0.25 ug Anti-Mouse VE-cadherin/CD144 Rabbit Recombinant Antibody (98251-1-RR, Clone: 241953D4) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98251-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98251-1-RR against Mouse VE-cadherin/CD144 were performed. The affinity constant is 1.65 nM.

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Applications testées

• Résultats positifs en cytométrie: cellules bEnd.3,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98251-1-RR cible VE-cadherin/CD144 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: cadherin 5
• Masse moléculaire calculée: 88kDa
• Numéro d’acquisition GenBank: NM_009868.4
• Symbole du gène: Cdh5
• Identification du gène (NCBI): 12562
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Vascular endothelial cadherin (VE-cadherin), also known as Cadherin-5 (CDH5) or CD144, is a member of the type II classical cadherin family of cell adhesion proteins (PMID: 21269602). VE-cadherin is expressed specifically in endothelial cells and mediates homophilic adhesion in the vascular endothelium (PMID: 1522121; 8555485; 21269602). VE-cadherin plays a role in the organization of lateral endothelial junctions and in the control of permeability properties of vascular endothelium (PMID: 1522121). VE-cadherin has also been shown to be required for angiogenesis (PMID: 16473763; 18162609).

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