Anticorps Recombinant de lapin anti-VEGFR2/CD309

VEGFR2/CD309 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240214D7

N° de cat : 98027-2-PBS

Synonymes

Kdr, Krd 1, Flk1, Flk 1, 6130401C07

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Galerie de données de validation

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  FC experiment of bEnd.3 using 98027-2-RR (same clone as 98027-2-PBS)

  1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse VEGFR2/CD309 Rabbit Recombinant Antibody (98027-2-RR, Clone: 240214D7) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98027-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98027-2-RR

  Biolayer interferometry (BLl) kinetic assays of 83376-7-RR against Mouse VEGFR-2/Kdr were performed. The affinity constant is 1.98 nM.

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Informations sur le produit

98027-2-PBS cible VEGFR2/CD309 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: kinase insert domain protein receptor
• Masse moléculaire calculée: 150KD
• Numéro d’acquisition GenBank: NM_010612.2
• Symbole du gène: VEGFR-2
• Identification du gène (NCBI): 16542
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

VEGFR2, also named as CD309, KDR and FLK1, is a receptor for VEGF or VEGFC. VEGFR2 which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGFR2 functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

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