Anticorps Recombinant de lapin anti-VEGFR1/Flt-1

VEGFR1/Flt-1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242311A4

N° de cat : 85761-4-PBS

Synonymes

Flt1, FLT-1, VEGFR-1, VGFR1

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Galerie de données de validation

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  WB analysis using 85761-4-RR (same clone as 85761-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85761-4-RR (VEGFR1/Flt-1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85761-4-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 85761-4-RR

  Biolayer interferometry (BLl) kinetic assays of 85761-4-RR against Rat VEGFR1/Flt-1 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

85761-4-PBS cible VEGFR1/Flt-1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons rat, souris

• Réactivité: rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: VEGFR1/Flt-1 Protéine recombinante Eg1167
• Nom complet: fms-related tyrosine kinase 1
• Poids moléculaire observé: 150-210 kDa
• Symbole du gène: Flt1
• Identification du gène (NCBI): 54251
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Vascular endothelial growth factor receptor-1 (VEGFR-1, FLT-1) is a receptor tyrosine kinase belonging to the VEGFR family. VEGF is a key regulator of physiological angiogenesis and has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders, and other conditions. The biological effects of VEGF are mediated by VEGFR-1 and VEGFR-2. Both the two receptors have seven immunoglobulin-like repeats in the extracellular domain, a single transmembrane region and a tyrosine kinase domain. VEGFR-1 binds VEGFA, PIGF, and VEGFB, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Two isoforms of VEGFR-1 exist, a full-length transmembrane form and a short soluble form (sVEGFR-1) consisting of only the extracellular ligand-binding domain. (PMID: 12778165; 17109193; 8806634)

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