Anticorps Recombinant de lapin anti-VEGFR2/CD309

VEGFR2/CD309 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

230238B11

N° de cat : 98009-1-RR

Synonymes

KDR, VEGFR2, VEGFR2/KDR, 230238B11, CD309

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Galerie de données de validation

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  FC experiment of HUVEC using 98009-1-RR

  1x10^6 HUVEC cells (left) or HeLa cells (right) were surface stained with 0.25 ug Anti-Human VEGFR2/CD309 Rabbit RecAb (98009-1-RR, Clone: 230238B11) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98009-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98009-1-RR against Human VEGFR2/CD309 were performed. The affinity constant is 30.6 nM.

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Applications testées

• Résultats positifs en cytométrie: cellules HUVEC,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98009-1-RR cible VEGFR2/CD309 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: VEGFR2/CD309 Protéine recombinante Eg0218
• Nom complet: kinase insert domain receptor (a type III receptor tyrosine kinase)
• Masse moléculaire calculée: 152 kDa
• Numéro d’acquisition GenBank: NM_002253
• Symbole du gène: KDR
• Identification du gène (NCBI): 3791
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

VEGFR2, also named as CD309, KDR and FLK1, is a receptor for VEGF or VEGFC. VEGFR2 which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGFR2 functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

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