Anticorps Recombinant de lapin anti-WBSCR17

WBSCR17 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250868B10

N° de cat : 86351-1-PBS

Synonymes

EC:2.4.1.41, GalNAc T like protein 3, GalNAc-T-like protein 3, GALNT17, Polypeptide GalNAc transferase-like protein 3

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Galerie de données de validation

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  WB analysis using 86351-1-RR (same clone as 86351-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86351-1-RR (WBSCR17 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86351-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86351-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86351-1-RR against Human WBSCR17 were performed. The affinity constant is 1.25 nM.

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Informations sur le produit

86351-1-PBS cible WBSCR17 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: WBSCR17 Protéine recombinante Ag15792
• Nom complet: Williams-Beuren syndrome chromosome region 17
• Masse moléculaire calculée: 598 aa, 68 kDa
• Poids moléculaire observé: 70~90 kDa
• Numéro d’acquisition GenBank: BC069624
• Symbole du gène: WBSCR17
• Identification du gène (NCBI): 64409
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

WBSCR17, also known as GALNT17, which encodes a brain-expressed N-acetylgalactosaminyl transferase (GalNAcT), is located at the distal edge of a region that is commonly deleted or duplicated in Williams Beuren Syndrome (WBS), a developmental disorder with motor and coordination problems, impaired visuospatial memory, and abnormal social interaction (PMID: 31554716). WBSCR17 loss-of-function has significant effects on cerebellar development, and is associated with phenotypes including developmental delay, deficits in motor coordination, reduced exploratory activity, and impaired social behavior (PMID: 22787146). With the calculated molecular mass of recombinant WBSCR17 being 68 kDa, the 70-90-kDa glycoproteins could also be detected due to post-translational modifications (PMID: 22787146).

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