Anticorps Polyclonal de lapin anti-WRN

WRN Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 25269-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of MCF-7 using 25269-1-AP (same clone as 25269-1-PBS)

  MCF-7 cells were subjected to SDS PAGE followed by western blot with 25269-1-AP (WRN Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25269-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 25269-1-AP (same clone as 25269-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 25269-1-AP (WRN Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25269-1-PBS in a different storage buffer formulation.

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Informations sur le produit

25269-1-PBS cible WRN dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: Werner syndrome, RecQ helicase-like
• Masse moléculaire calculée: 162 kDa
• Poids moléculaire observé: 162 kDa
• Numéro d’acquisition GenBank: NM_000553
• Symbole du gène: WRN
• Identification du gène (NCBI): 7486
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Werner syndrome ATP dependent helicase (WRN) ,also named as RECQ3 or RecQ protein like 2, is a 1432 amino acid protein, which contains one HRDC domain, one helicase C-terminal domain, one helicase ATP-binding domain and 3'-5' exonuclease domain. WRN localizes in the nucleoplasm and belongs to the helicase family. WRN plays a central role in the repair of methylation-induced DNA damage and has an helicase activity necessary to prevent dramatic telomere loss during DNA replication. WRN gene mutation has an association with Werner syndrome and colorectal cancer.

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