Anticorps Monoclonal anti-WWP2

WWP2 Monoclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2C9B4

N° de cat : 67274-1-PBS

Synonymes

AIP2, WW domain containing protein 2, WWP2, WWp2 like

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Galerie de données de validation

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  WB analysis using 67274-1-Ig (same clone as 67274-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67274-1-Ig (WWP2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67274-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 67274-1-Ig (same clone as 67274-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 67274-1-Ig (WWP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67274-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 67274-1-Ig (same clone as 67274-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 67274-1-Ig (WWP2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67274-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67274-1-PBS cible WWP2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: WWP2 Protéine recombinante Ag2835
• Nom complet: WW domain containing E3 ubiquitin protein ligase 2
• Masse moléculaire calculée: 870 aa, 99 kDa
• Poids moléculaire observé: 100-115 kDa
• Numéro d’acquisition GenBank: BC013645
• Symbole du gène: WWP2
• Identification du gène (NCBI): 11060
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

WWP2 (WW domain-containing protein 2) is also named as AIP2 and belongs to the NEDD4-like protein family. It functions as an E3 ubiquitin ligase for PTEN that plays a vital role in tumour-cell survival and is also involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes (PMID:21532586). WWP2, which specifically interacted with ES cell-specific transcription factor Oct-4 and promoted its ubiquitination both in vitro and in vivo, is a ubiquitously expressed protein and exists in both cytoplasmic and nuclear compartments in ES cells (PMID:15047715).

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