Anticorps Polyclonal de lapin anti-XPC

XPC Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33279-1-PBS

Synonymes

DNA repair protein complementing XP-C cells, p125, Xeroderma pigmentosum group C-complementing protein, XPCC

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Galerie de données de validation

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  WB analysis using 33279-1-AP (same clone as 33279-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33279-1-AP (XPC antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33279-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33279-1-PBS cible XPC dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: XPC Protéine recombinante Ag38513
• Nom complet: xeroderma pigmentosum, complementation group C
• Masse moléculaire calculée: 106kDa，940aa
• Poids moléculaire observé: 106-120 kDa
• Numéro d’acquisition GenBank: NM_004628.4
• Symbole du gène: XPC
• Identification du gène (NCBI): 7508
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

XPC (DNA repair protein complementing XP-C cells) protein is a pivotal DNA damage recognition factor that plays an indispensable role in the global-genome nucleotide excision repair (GG-NER) pathway. As the primary initiator of GG-NER, it acts as a universal sensor for a wide array of helix-distorting DNA lesions, including those induced by ultraviolet (UV) radiation and chemical carcinogens. Upon binding to damaged DNA, the XPC complex orchestrates the recruitment of the entire repair machinery, serving as a critical guardian of genomic integrity. The calculated molecular weight of XPC is about 106 kDa, but due to post-translational modifications, about 120 kDa will be observed.

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