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Anticorps Polyclonal de lapin anti-CRM1

CRM1 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB,ELISA

Conjugaison

Non conjugué

N° de cat : 12915-1-AP

Synonymes

CRM1, Exp1, Exportin 1, XPO1

Galerie de données de validation

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  • Western Blot (WB) analysis of HT-1080 cells using CRM1 Polyclonal antibody (12915-1-AP)

    WB analysis of HT-1080 using 12915-1-AP

    HT-1080 cells were subjected to SDS PAGE followed by western blot with 12915-1-AP (CRM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of human kidney tissue using CRM1 Polyclonal antibody (12915-1-AP)

    IHC staining of human kidney using 12915-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human kidney tissue using CRM1 Polyclonal antibody (12915-1-AP)

    IHC staining of human kidney using 12915-1-AP

    Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 40x lens).

Applications testées

Dilution recommandée

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

WBSee 1 publications below

Informations sur le produit

12915-1-AP cible CRM1 dans les applications de WB,ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Réactivité citéeHumain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène CRM1 Protéine recombinante Ag3488
Nom complet exportin 1 (CRM1 homolog, yeast)
Masse moléculaire calculée 1071 aa, 123 kDa
Poids moléculaire observé 100-110 kDa
Numéro d’acquisition GenBankBC032847
Symbole du gène XPO1
Identification du gène (NCBI) 7514
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).

Publications

SpeciesApplicationTitle
humanWB

Toxicology

Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.

Authors - Chuanyang Su
View Article