Anticorps Polyclonal de lapin anti-CRM1

CRM1 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(1)

N° de cat : 12915-1-AP

Synonymes

CRM1, Exp1, Exportin 1, XPO1

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Galerie de données de validation

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  WB analysis of HT-1080 using 12915-1-AP

  HT-1080 cells were subjected to SDS PAGE followed by western blot with 12915-1-AP (CRM1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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  IHC staining of human kidney using 12915-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human kidney using 12915-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney using 12915-1-AP (CRM1 antibody) at dilution of 1:50 (under 40x lens).

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Applications publiées

• WB: See 1 publications below

Informations sur le produit

12915-1-AP cible CRM1 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CRM1 Protéine recombinante Ag3488
• Nom complet: exportin 1 (CRM1 homolog, yeast)
• Masse moléculaire calculée: 1071 aa, 123 kDa
• Poids moléculaire observé: 100-110 kDa
• Numéro d’acquisition GenBank: BC032847
• Symbole du gène: CRM1
• Identification du gène (NCBI): 7514
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

CRM1 (chromosome region maintenance 1, also known as exportin-1 or XPO1), a member of the karyopherin β family of transport receptors, is an important nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal (PMID: 9323133). CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs (PMID: 17317185). In addition to nuclear export, CRM1 also plays a role in centrosome duplication and spindle assembly (PMID: 22773955). Elevated CRM1 expression has been reported in several cancers, which implicates CRM1 as a potential anti-cancer drug target (PMID: 22677130; 21683812 ).

Publications

Species	Application	Title
human	WB	Toxicology; Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.; Authors - Chuanyang Su

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