Anticorps Recombinant de lapin anti-XPR1

XPR1 Recombinant Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241788A7

N° de cat : 84902-1-PBS

Synonymes

241788A7, Phosphate exporter SLC53A1, Protein SYG1 homolog, SLC53A1, Solute carrier family 53 member 1

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Galerie de données de validation

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  WB analysis using 84902-1-RR (same clone as 84902-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84902-1-RR (XPR1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84902-1-PBS in a different storage buffer formulation.

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  IP experiment of Jurkat using 84902-1-RR (same clone as 84902-1-PBS)

  IP result of anti-XPR1 (IP:84902-1-RR, 4ug; Detection:84902-1-RR 1:1000) with Jurkat cells lysate 1800 ug. This data was developed using the same antibody clone with 84902-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84902-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84902-1-RR against Human XPR1 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

84902-1-PBS cible XPR1 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: XPR1 Protéine recombinante Ag5373
• Nom complet: xenotropic and polytropic retrovirus receptor
• Masse moléculaire calculée: 696 aa, 82 kDa
• Poids moléculaire observé: 74 kDa
• Numéro d’acquisition GenBank: BC041142
• Symbole du gène: XPR1
• Identification du gène (NCBI): 9213
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

XPR1 is a receptor for xenotropic and polytropic murine leukemia retroviruses and a homolog of yeast Syg1 and plant Pi transporter PHO1 (PMID: 20633538). XPR1 has been identified as an atypical G-protein-coupled receptor. Xenotropic or polytropic retrovirus binding to XPR1 can disrupt the cAMP-mediated signaling function of Xpr1, leading to the apoptosis of infected cells (PMID: 22090134). A band of about 82-100 kDa is probably due to abnormal migration of the protein or post-translation modifications. In addition, a band of about 55-72 kDa may be isoforms and fragments.

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