Anticorps Polyclonal de lapin anti-YEATS2

• Phare
• Validé par KD/KO

YEATS2 Polyclonal Antibody for WB, IP, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (1)

Applications

WB, IHC, IP, ChIP, ELISA

Conjugaison

Non conjugué

Publications(10)

N° de cat : 24717-1-AP

Synonymes

KIAA1197, YEATS domain containing 2, YEATS domain-containing protein 2

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Galerie de données de validation

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  WB analysis of HEK-293 using 24717-1-AP

  WB result of YEATS2 antibody (24717-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-YEATS2 transfected HEK-293 cells.

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  WB analysis of Jurkat using 24717-1-AP

  Jurkat cells were subjected to SDS PAGE followed by western blot with 24717-1-AP (YEATS2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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  IP experiment of Jurkat using 24717-1-AP

  IP result of anti-YEATS2 (IP:24717-1-AP, 5ug; Detection:24717-1-AP 1:300) with Jurkat cells lysate 2000ug.

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Applications testées

• Résultats positifs en WB: cellules Jurkat,
• Résultats positifs en IP: cellules Jurkat

Dilution recommandée

• Western Blot (WB): WB : 1:200-1:1000
• Immunoprécipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 3 publications below
• WB: See 9 publications below
• IHC: See 4 publications below
• IP: See 2 publications below
• ChIP: See 1 publications below

Informations sur le produit

24717-1-AP cible YEATS2 dans les applications de WB, IHC, IP, ChIP, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: YEATS2 Protéine recombinante Ag20134
• Nom complet: YEATS domain containing 2
• Masse moléculaire calculée: 1422 aa, 151 kDa
• Poids moléculaire observé: 151 kDa
• Numéro d’acquisition GenBank: BC150273
• Symbole du gène: YEATS2
• Identification du gène (NCBI): 55689
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

YEATS domain containing 2 (YEATS2) protein is a scaffolding subunit of the ATAC complex. Studies have shown that YEATS2 is a selective histone crotonylation reader and is related to histone acetylation. In addition, YEATS2 is associated with the progression of various tumors. Overexpression of YEATS2 promotes the proliferation and migration of pancreatic cancer cells. YEATS2 has been reported to be associated with the progression of non-small-cell lung cancer through histone acetylation.

Publications

Species	Application	Title
human	WB	Nat Commun; YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.; Authors - Wenyi Mi ; KD Validated
human	WB,IP,IHC	Cell Biol Toxicol; YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.; Authors - Hao Sheng ; KD Validated
human	WB,IHC	J Cell Physiol; YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.; Authors - Zhirui Zeng ; KD Validated
human	WB	Signal Transduct Target Ther; Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.; Authors - Yiyi Xi
mouse	WB,IHC	Phytomedicine; Cinobufacini retards progression of pancreatic ductal adenocarcinoma through targeting YEATS2/TAK1/NF-κB axis; Authors - Tian Lan
human	WB	Cancers (Basel); Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway; Authors - Xin Liu

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