Anticorps Polyclonal de lapin anti-YKT6

YKT6 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33685-1-PBS

Synonymes

EC:2.3.1.-, Synaptobrevin homolog YKT6, YKT6 V-SNARE Homolog

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Galerie de données de validation

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  WB analysis using 33685-1-AP (same clone as 33685-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33685-1-AP (YKT6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33685-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33685-1-PBS cible YKT6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: YKT6 Protéine recombinante Ag38740
• Nom complet: YKT6 v-SNARE homolog (S. cerevisiae)
• Masse moléculaire calculée: 22 kDa
• Poids moléculaire observé: 25 kDa
• Numéro d’acquisition GenBank: BC007319
• Symbole du gène: YKT6
• Identification du gène (NCBI): 10652
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

YKT6 is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) that plays a central role in membrane fusion in eukaryotic cells. It is primarily localized in the cytoplasm and, through its unique dual lipidation modification (palmitoylation and farnesylation), can associate with various organelle membranes, such as the Golgi apparatus, endosomes, and vesicles. By forming stable trans-SNARE complexes with other SNARE proteins (e.g., Syntaxin and SNAP-25 family members) on target membranes, YKT6 provides the driving force for membrane fusion, thereby facilitating intracellular trafficking. This protein is essential for maintaining organelle integrity, autophagy, and secretory pathways. Studies have shown that dysfunction of YKT6 is associated with various diseases, including cancer, neurodegenerative disorders, and metabolic abnormalities, making it a potential target for drug development.

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