- Phare
- Validé par KD/KO
Anticorps Recombinant de lapin anti-YTHDF2
YTHDF2 Recombinant Antibody for WB, IF/ICC, IP, Indirect ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain, rat, souris
Applications
WB, IF/ICC, IP, Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
3L6
N° de cat : 81340-1-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
81340-1-PBS cible YTHDF2 dans les applications de WB, IF/ICC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris
Réactivité | Humain, rat, souris |
Hôte / Isotype | Lapin / IgG |
Clonalité | Recombinant |
Type | Anticorps |
Immunogène | YTHDF2 Protéine recombinante Ag5922 |
Nom complet | YTH domain family, member 2 |
Masse moléculaire calculée | 62 kDa |
Poids moléculaire observé | 65-70 kDa |
Numéro d’acquisition GenBank | BC002559 |
Symbole du gène | YTHDF2 |
Identification du gène (NCBI) | 51441 |
Conjugaison | Non conjugué |
Forme | Liquide |
Méthode de purification | Purification par protéine A |
Tampon de stockage | PBS only |
Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
YTHDF2, also named as YTH domain-containing family protein 2, is a 579 amino acid protein, which contains 1 YTH domain. YTHDF2 specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. YTHDF2 acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. YTHDF2 also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation. The calculated molecular weight of YTHDF2 is 62 kDa, but the phosphorylated YTHDF2 is about 65-70 kDa.