Anticorps Polyclonal de lapin anti-ZBTB17

ZBTB17 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

Conjugaison

Non conjugué

N° de cat : 22691-1-AP

Synonymes

MIZ 1, MIZ1, pHZ 67, Zinc finger protein 151, Zinc finger protein 60

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Galerie de données de validation

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  WB analysis using 22691-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22691-1-AP (ZBTB17 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

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  WB analysis using 22691-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22691-1-AP (ZBTB17 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules Jurkat, cellules NIH/3T3, cellules THP-1

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:5000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

22691-1-AP cible ZBTB17 dans les applications de et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ZBTB17 Protéine recombinante Ag18396
• Nom complet: zinc finger and BTB domain containing 17
• Masse moléculaire calculée: 803 aa, 88 kDa
• Poids moléculaire observé: 88-100 kDa
• Numéro d’acquisition GenBank: BC126163
• Symbole du gène: ZBTB17
• Identification du gène (NCBI): 7709
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purifié par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

ZBTB17 (zinc finger and BTB domain protein 17), also known as MIZ1, is a highly conserved transcription factor in evolution. It is expressed in many cell types and plays an important role in many biological processes such as cell cycle regulation, immune cell development and metabolic regulation. ZBTB17 plays a key role in the early stage of T cell development. It ensures the normal development of T cells by regulating the expression of pre-TCR and inhibiting the activity of TP53. ZBTB17 plays an important role in cardiac stress response, and its absence may lead to cardiomyopathy and heart failure. At Lys-397 and Lys-481, it undergoes "Lys-48" linked ubiquitination, and then degrades proteasome in a TRAF2-dependent manner.

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