Anticorps Polyclonal de lapin anti-ZFP64

ZFP64 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 17187-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse spleen using 17187-1-AP (same clone as 17187-1-PBS)

  mouse spleen tissue were subjected to SDS PAGE followed by western blot with 17187-1-AP (ZFP64 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17187-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 17187-1-AP (same clone as 17187-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 17187-1-AP (ZFP64 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17187-1-PBS in a different storage buffer formulation.

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Informations sur le produit

17187-1-PBS cible ZFP64 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ZFP64 Protéine recombinante Ag10971
• Nom complet: zinc finger protein 64 homolog (mouse)
• Masse moléculaire calculée: 681 aa, 75 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: BC041622
• Symbole du gène: ZFP64
• Identification du gène (NCBI): 55734
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ZFP64 (also known as ZNF338) is a member of the Krüppel C2H2-type zinc finger family. ZFP64 is a coactivator of Notch1, mediating mesenchymal cell differentiation. ZFP64 expression was up-regulated in mouse peritoneal macrophages in response to stimulation with the TLR4 ligand LPS with a 2-fold increase. The MLL gene encoding the MLL fusion protein is easily activated by ZFP64. ZFP64 is essential for the continuous production of MLL fusion proteins in blood cancer and produces more cancer cells. Since ZFP64 deletion completely and specifically inhibits MLL fusion protein production and leukemia cascade growth, it is an ideal drug target.

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