Anticorps Recombinant de lapin anti-ZNF238/ZBTB18

ZNF238/ZBTB18 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251389B9

N° de cat : 86544-3-PBS

Synonymes

ZNF238, 58 kDa repressor protein, C2H2 171, RP58, TAZ 1

---

Galerie de données de validation

• 

  WB analysis using 86544-3-RR (same clone as 86544-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86544-3-RR (ZNF238 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86544-3-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 86544-3-RR

  Biolayer interferometry (BLl) kinetic assays of 86544-3-RR against Human ZNF238/ZBTB18 were performed. The affinity constant is below 1 pM.

---

Informations sur le produit

86544-3-PBS cible ZNF238/ZBTB18 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ZNF238/ZBTB18 Protéine recombinante Ag3406
• Nom complet: zinc finger protein 238
• Masse moléculaire calculée: 531 aa, 59 kDa
• Poids moléculaire observé: 48 kDa
• Numéro d’acquisition GenBank: BC036677
• Symbole du gène: ZNF238/ZBTB18
• Identification du gène (NCBI): 10472
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ZNF238 is a member of the BTB/POZ-ZF protein family, which involve in development and cancer formation, for example BCL-6, PLZF, and HIC-1. It's a transcriptional repressor involve in myogenesis and brain development. By directly repressing the expression of two skeletal myogenesis inhibitors, ID2 and ID3, ZNF238 plays a key role in myogenesis. It can control cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Besides, ZNF238 involves in the organization of nuclear chromosomes, for its specific binding to the consensus DNA sequence that contains the E box core, and recruiting chromatin remodeling multi-protein complex. ZNF238 proteins has apparent molecular masses of 60 and 48 kD. Specific binding is found for a 60-kDa band which corresponds to the full length of RP58 protein. In addition, a 48-kDa band, thought to be the truncated form 2 is detected (PMID: 9756912).

{{ptg:RelatedPrimaryAntibodies}}