Anticorps Polyclonal de lapin anti-ZNF746

• Phare
• Validé par KD/KO

ZNF746 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24543-1-PBS

Synonymes

Zinc finger protein 746, Parkin-interacting substrate, PARIS, FLJ31413

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Galerie de données de validation

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  WB analysis using 24543-1-AP (same clone as 24543-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24543-1-AP (ZNF746 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24543-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293T using 24543-1-AP (same clone as 24543-1-PBS)

  HEK-293T cells were subjected to SDS PAGE followed by western blot with 24543-1-AP (ZNF746 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24543-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24543-1-PBS cible ZNF746 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ZNF746 Protéine recombinante Ag21566
• Nom complet: zinc finger protein 746
• Masse moléculaire calculée: 644 aa, 69 kDa
• Poids moléculaire observé: 85-95 kDa
• Numéro d’acquisition GenBank: BC068505
• Symbole du gène: ZNF746
• Identification du gène (NCBI): 155061
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN (PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).

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