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Anticorps Monoclonal anti-NeutraKine® Beta NGF

NeutraKine® Beta NGF Monoclonal Antibody for Neutralization, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

Neutralization, ELISA

Conjugaison

Non conjugué

CloneNo.

4F9H1

N° de cat : 69009-1-Ig

Synonymes

Beta nerve growth factor, Beta NGF, HSAN5, NeutraKine® Beta NGF, NGF, NGFB, proNGF

Galerie de données de validation

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  • Neutralization experiment of NeutraKine® Beta NGF using NeutraKine® Beta NGF Monoclonal antibody (69009-1-Ig)

    Neutralization experiment of NeutraKine® Beta NGF using 69009-1-Ig

    Recombinant human beta-NGF (Cat.NO. HZ-1222) stimulates proliferation of TF-1 cell line (human erythroleukemic cell line) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human beta-NGF (2 ng/mL HZ-1222) is neutralized by mouse anti-human beta-NGF monoclonal antibody 69009-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 4-20 ng/mL.

Neutralization mesurée par sa capacité à neutraliser la prolifération induite par le bêta-NGF humain de la lignée cellulaire TF-1 (lignée cellulaire érythroleucémique humaine). La dose de demi-neutralisation (DN50) est typiquement de 4 à 20 ng/ml en présence de 2 ng/ml de bêtaNGF humain.

Informations sur le produit

69009-1-Ig cible NeutraKine® Beta NGF dans les applications de Neutralization, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Mouse / IgG1
Clonalité Monoclonal
Type Anticorps
Immunogène human Humankine Beta NGF protein HZ-1222
Nom complet nerve growth factor (beta polypeptide)
Symbole du gène NGF
Identification du gène (NCBI) 4803
Conjugaison Non conjugué
Forme Lyophilized Powder
Méthode de purification Purification par protéine G
Tampon de stockage PBS stérile.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Informations générales

Beta nerve growth factor (NGF) is critical for the survival and maintenance of sympathetic and sensory neurons and may play an important role in the regulation of the immune system (PMID 16842161). The presence of beta NGF in immune cells, endocrine cells, and the CNS limbic areas suggests that beta NGF may function as an intracellular messenger to regulate the body's response to stress (PMID 19442684).

This antibody can be used to neutralize the bioactivity of Beta NGF.