Anticorps Monoclonal anti-c-Cbl

• Phare
• Validé par KD/KO

c-Cbl Monoclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2F6D1

N° de cat : 66576-1-PBS

Synonymes

C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55

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Galerie de données de validation

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  WB analysis using 66576-1-Ig (same clone as 66576-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 66576-1-Ig (c-Cbl antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

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  WB analysis of Daudi using 66576-1-Ig (same clone as 66576-1-PBS)

  Daudi cells were subjected to SDS PAGE followed by western blot with 66576-1-Ig (CBL antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 66576-1-Ig (same clone as 66576-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66576-1-Ig (CBL antibody) at dilution of 1:600 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

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  IHC staining of human tonsillitis using 66576-1-Ig (same clone as 66576-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 66576-1-Ig (CBL antibody) at dilution of 1:600 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66576-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66576-1-PBS cible c-Cbl dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: c-Cbl Protéine recombinante Ag23033
• Nom complet: Cas-Br-M (murine) ecotropic retroviral transforming sequence
• Masse moléculaire calculée: 906 aa, 100 kDa
• Poids moléculaire observé: 100-120 kDa
• Numéro d’acquisition GenBank: BC132733
• Symbole du gène: CBL
• Identification du gène (NCBI): 867
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

c-Cbl (Casitas B-lineage lymphoma) is a critical regulator that controls immature or follicular helper T cell development, B cell development, immune tolerance, angiogenesis, or tumorigenesis (PMID: 33962939). c-Cbl also plays a pivotal role in regulating dendritic cell (DC) function via negatively modulating IL-12 production after Toll-like receptor (TLR) stimulation (PMID: 21799517).

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