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Anticorps Recombinant de lapin anti-gp130/IL6ST

gp130/IL6ST Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242236E1

N° de cat : 84794-4-PBS

Synonymes

242236E1, CD130, gp130, IL-6 receptor subunit beta, IL-6R subunit beta

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using gp130/IL6ST Recombinant antibody (84794-4-RR)

    WB analysis using 84794-4-RR (same clone as 84794-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84794-4-RR (gp130/IL6ST antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84794-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84794-4-RR

    Affinity and Kinetic Characterization of 84794-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84794-4-RR against Mouse gp130/IL6ST were performed. The affinity constant is 89.7 pM.

Informations sur le produit

84794-4-PBS cible gp130/IL6ST dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène gp130/IL6ST Protéine recombinante Eg1631
Nom complet interleukin 6 signal transducer
Masse moléculaire calculée102kDa, 917aa
Poids moléculaire observé140 kDa
Numéro d’acquisition GenBankNM_010560.3
Symbole du gène Il6st
Identification du gène (NCBI) 16195
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GP130, also known as IL6ST, is a transmembrane protein that serves as a shared signal-transducing subunit for a variety of cytokines(PMID: 39414364), including interleukin-6 (IL-6), IL-11, IL-27, leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC)/CLC factor 1 (CLCF-1), and neuropoietin (PMID: 24099136). This protein is highly conserved among vertebrates and plays a crucial role in mediating interactions between a wide range of immune and non-immune cells. GP130 was originally discovered in 1978 and was successfully cloned and expressed in 1990, leading to a deeper understanding of cytokine signaling pathways (PMID: 308233).

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