Anticorps Recombinant de lapin anti-nectin 4
nectin 4 Recombinant Antibody for Cytometric bead array, Indirect ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain
Applications
Cytometric bead array, Indirect ELISA
Conjugaison
Non conjugué
CloneNo.
240009G5
N° de cat : 83223-2-PBS
Synonymes
Galerie de données de validation
Informations sur le produit
83223-2-PBS cible nectin 4 dans les applications de Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Recombinant |
| Type | Anticorps |
| Immunogène | nectin 4 Protéine recombinante Eg0415 |
| Nom complet | poliovirus receptor-related 4 |
| Masse moléculaire calculée | 510 aa, 55 kDa |
| Numéro d’acquisition GenBank | BC010423 |
| Symbole du gène | Nectin-4 |
| Identification du gène (NCBI) | 81607 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par protéine A |
| Tampon de stockage | PBS only |
| Conditions de stockage | Store at -80°C. 20ul contiennent 0,1% de BSA. |
Informations générales
Nectin-4, also known as PVRL4, is a type-I transmembrane glycoprotein that belongs to the nectin subfamily of immunoglobulin-like adhesion molecules that participate in Ca(2+)-independent cell-cell adhesion (PMID: 18703497). The extracellular domain of Nectin-4, which contains three immunoglobulin-like domains (V and two C2-type domains, VCC), can be proteolytically cleaved to release a soluble form. Nectin-4 interacts with afadin via its carboxyl-terminal cytoplasmic sequence and trans-interacts with nectin-1/PRR1 through V domain interaction (PMID: 11544254). It acts as a receptor for measles virus (PMID: 22048310). Nectin-4 is overexpressed in multiple human malignancies and the aberrant expression is correlated with cancer progression and poor prognostic (PMID: 35131876). Nectin-4 can be detected as a soluble form of 43 kDa and a transmembrane form of 66 kDa (PMID: 15784625).
