Anticorps Monoclonal anti-p120 Catenin

• Phare
• Validé par KD/KO

p120 Catenin Monoclonal Antibody for IF/ICC, IF-P

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain, rat, souris

Applications

IF/ICC, IF-P

Conjugaison

CoraLite®594 Fluorescent Dye

CloneNo.

2F7H8

N° de cat : CL594-66208

Synonymes

CAS, Catenin delta 1, CTNND, CTNND1, KIAA0384, p120, p120 catenin, p120(cas), p120(ctn), P120CAS, P120CTN

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Galerie de données de validation

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  IF Staining of human breast cancer using CL594-66208

  Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using the CoraLite®594-conjugated version of this antibody, CL594-66208 (p120 Catenin antibody), at dilution of 1:100.

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  IF Staining of human breast cancer using CL594-66208

  Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using the CoraLite®594-conjugated version of this antibody, CL594-66208 (p120 Catenin antibody), at dilution of 1:100.

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  IF Staining of MCF-7 using CL594-66208

  Immunofluorescent analysis of (-20°C Ethanol) fixed MCF-7 cells using CL594-66208 (p120 Catenin antibody) at dilution of 1:100.

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Applications testées

• Résultats positifs en IF-P: tissu de cancer du sein humain,
• Résultats positifs en IF/ICC: cellules MCF-7, tissu de cancer du sein humain

Dilution recommandée

• Immunofluorescence (IF)-P: IF-P : 1:50-1:500
• Immunofluorescence (IF)/ICC: IF/ICC : 1:50-1:500

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

CL594-66208 cible p120 Catenin dans les applications de IF/ICC, IF-P et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: p120 Catenin Protéine recombinante Ag2824
• Nom complet: catenin (cadherin-associated protein), delta 1
• Masse moléculaire calculée: 948 aa, 105 kDa
• Poids moléculaire observé: 90-120 kDa
• Numéro d’acquisition GenBank: BC010501
• Symbole du gène: p120 Catenin
• Identification du gène (NCBI): 1500
• Conjugaison: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
• Conditions de stockage: Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins (PMID: 9653641). p120 catenin, also called p120 ctn or catenin delta-1, regulates cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins. p120 catenin is a tyrosine kinase substrate implicated in cell transformation by SRC, as well as in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor, and the CSF1 receptor. Different expression patterns of p120 catenin in lobular and ductal carcinomas of breast have been reported: membrane stain for ductal carcinoma and cytoplasmic stain for lobular carcinoma (PMID: 24966968). Different isoforms of p120 catenin are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons (PMID: 19150613).

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