Anticorps Recombinant de lapin anti-uPAR/CD87

uPAR/CD87 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242976A9

N° de cat : 98424-3-PBS

Synonymes

CD87, Plaur, uPAR, U-PAR, Urokinase plasminogen activator surface receptor

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98424-3-RR (same clone as 98424-3-PBS)

  1x10^6 HEK-293T cells or uPAR/CD87 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse uPAR/CD87 Rabbit RecAb (98424-3-RR, Clone: 242976A9) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98424-3-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98424-3-RR (same clone as 98424-3-PBS)

  1x10^6 HEK-293T cells or uPAR/CD87 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Mouse uPAR/CD87 Rabbit RecAb (98424-3-RR, Clone: 242976A9) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98424-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98424-3-PBS cible uPAR/CD87 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: uPAR/CD87 Protéine recombinante Eg3156
• Nom complet: plasminogen activator, urokinase receptor
• Masse moléculaire calculée: 35 kDa
• Numéro d’acquisition GenBank: NM_011113.4
• Symbole du gène: Plaur
• Identification du gène (NCBI): 18793
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

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