Anticorps Recombinant de lapin anti-uPAR/CD87

uPAR/CD87 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

CoraLite®594 Fluorescent Dye

CloneNo.

240366G10

N° de cat : CL594-98048

Synonymes

PLAUR, UPAR, U PAR, MO3, CD87

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Galerie de données de validation

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  FC experiment of U-937 using CL594-98048

  1x10^6 PMA treated U-937 cells were surface stained with 5 ul CoraLite®594 Anti-Human uPAR/CD87 Rabbit Recombinant Antibody (CL594-98048, Clone: 240366G10) (red), or Isotype Control (blue). 1x10^6 untreated U-937 cells were surface stained with 5 ul CoraLite®594 Anti-Human uPAR/CD87 Rabbit Recombinant Antibody (CL594-98048, Clone: 240366G10) (black). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: PMA treated U-937 cells,

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

CL594-98048 cible uPAR/CD87 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: PLAUR
• Masse moléculaire calculée: 37 kDa
• Numéro d’acquisition GenBank: NM_002659.4
• Symbole du gène: uPAR
• Identification du gène (NCBI): 5329
• Conjugaison: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 588 nm / 604 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

uPAR, also known as CD87, is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

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