Activation Inhibition Indirectly activation Translocation Phosphorylation P Degradation Apoptosis Apoptosis Necroptosis Chromatindegradation DNA Fragmentation DNA Damage Cell Survival ER Stress FasL TRAIL DR4/5 Fas TNFReceptor cIAP1/2 Casp 8/10 Casp 3/7 Casp 9 Casp 12 Cyto c APAF1 FADD TAB1/2 TAK1 IKKα IKKβ NEMO NF-κB NF-κB NF-κB IκBα IκBα TRAF2/5 BAK BAX BAD PUMA Noxa Calpain DIABLO TRADD BID tBID AIF DFF40 DFF40 DFF45 ENDOG BCL2 XIAP Bcl-XL RIPK1 Casp 8/10 FADD RIPK1 complexa MLKL RIPK3 Casp 8/10 FADD RIPK1 complexb P P P RIPK3 MLKL MLKL MLKL complex Apoptosome p53 P P P P P P Cytoplasm Nucleus Ca 2+ Ca 2+ Ca 2+ Na + Na + Na +