Alpha-2-macroglobulin Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 13545-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human blood tissue, HepG2 cells, human brain tissue, human plasma tissue

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human liver tissue,human ovary tissue, human stomach tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:2000-1:12000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
alpha-2-macroglobulin

Calculated molecular weight:
1474aa,163 kDa

Observed molecular weight:
185 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
A2M

Synonyms
A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, DKFZp779B086, FWP007, S863 7, α-2M
Background

alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.


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