ACAT1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 16215-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human skeletal muscle tissue, human heart tissue

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
acetyl-Coenzyme A acetyltransferase 1

Calculated molecular weight:
45 kDa

Observed molecular weight:
45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ACAT1

Synonyms
ACAT, ACAT1, Acetoacetyl CoA thiolase, MAT, T2, THIL
Background

ACAT1 and ACTA2 are intracellular enzymes that convert free cholesterol to cholesteryl esters and play important roles in lipid metabolism. ACAT1 is widely expressed while ACTA2 is primarily expressed in intestine and liver. As the major ACAT isozyme in macrophages, ACTA1 plays an key role in foam cell formation and atherosclerosis, making it an appealing drug target for treating cardiovascular diseases. Recently it has been reported that ACTA1 is commonly activated by upregulated tetramerization in human cancers and is a promising anti-cancer target.


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