AFF4 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 14662-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 22 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
L02 cells, HeLa cells, HepG2 cells

Positive IP detected in:
HepG2 cells

Positive IF detected in:
L02 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
AF4/FMR2 family, member 4

Calculated molecular weight:
127 kDa

Observed molecular weight:
140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AFF4

Synonyms
AF4/FMR2 family member 4, AF4/FMR2 family, member 4, AF5Q31, AFF4, MCEF, Protein AF 5q31
Background

Transcriptional controled by RNA polymerase II (Pol II) is a multi-step process requiring the concerted action of multiple factors and contacts with the DNA template for the proper synthesis of nascent RNA [PMID:12676794]. ELL1 was demonstrated to be a Pol II elongation factor capable of enhancing the catalytic rate of transcription elongation by reducing transient pausing by the enzyme [PMID:8596958]. AFF4 was initially identified as a fusion partner of the MLL (mixed-lineage leukemia) gene participated in infant acute lymphoblastic leukemia, and a component of the ELL/p-TEFb elongation complex. AFF4 interacts with positive transcription elongation factor-b while also repressing Tat transactivation of HIV-1 [PMID:17389929].


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