AFG3L2 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 14631-1-AP

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Con: 54 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, mouse liver tissue, HEK-293 cells, mouse kidney tissue, mouse brain tissue, mouse skeletal muscle tissue, human brain tissue, mouse heart tissue

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human kidney tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
AFG3 ATPase family gene 3-like 2 (yeast)

Calculated molecular weight:
88 kDa

Observed molecular weight:
80-90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

AFG3 like protein 2, AFG3L2, Paraplegin like protein

AFG3L2 is the catalytic subunit of the m-AAA protease, an ATP-dependent proteolytic complex of the mitochondrial inner membrane that degrades misfolded proteins and regulates ribosome assembly(PMID:17101804). Human AFG3L2 is an 80-kDa protein encoded by a 17-exon gene and highly and selectively expressed in human cerebellar Purkinje cells(PMID:20208537) and it can exsit as a truncated 65 kDa protein(PMID:18337413). Defects in AFG3L2 are the cause of spinocerebellar ataxia type 28 (SCA28) and spastic ataxia autosomal recessive type 5 (SPAX5).

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