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AGTR1 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 25343-1-AP

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Con: 47 μg/150 μl

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Tested Applications

Applications:
WB, IHC, IF, ELISA
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Images See all

AGTR1 Antibody WB C2C12 cells 25343-1-AP

Various lysates were subjected to SDS PAGE followed by western blot with 25343-1-AP (AGTR1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

AGTR1 Antibody IHC human heart tissue 25343-1-AP

Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 25343-1-AP( AGTR1 Antibody) at dilution of 1:50 (under 10x lens)

AGTR1 Antibody IHC human heart tissue 25343-1-AP

Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 25343-1-AP( AGTR1 Antibody) at dilution of 1:50 (under 40x lens)

Species specificity:
human, mouse, rat
Positive WB detected in:
C2C12 cells, PC-12 cells, mouse kidney tissue, mouse heart tissue, HuH-7 cells, HEK-293 cells
Positive IHC detected in:
human heart tissue, human liver cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
AGTR1 fusion protein Ag14461
Full name:
angiotensin II receptor, type 1
Calculated molecular weight:
359aa,41 kDa
Observed molecular weight:
50 kDa
GenBank accession number:
BC022447
Gene ID (NCBI):
185
Gene symbol
AGTR1
Synonyms
AG2S, AGTR1, AGTR1A, AGTR1B, Angiotensin II type 1 receptor, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, Type 1 angiotensin II receptor

Background

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).


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