AIM2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 20590-1-AP

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Freight/Packing

Con: 86 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, A549 cells, COLO 320 cells, HeLa cells, HepG2 cells, Jurkat cells, MCF-7 cells, mouse testis tissue, rat testis tissue, SH-SY5Y cells

Positive IHC detected in:
human testis tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
absent in melanoma 2

Calculated molecular weight:
343aa,39 kDa

Observed molecular weight:
39-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AIM2

Synonyms
absent in melanoma 2, AIM2, PYHIN4
Background

Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID: 22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831].


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