AKAP7 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 12591-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 24 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, human brain tissue, human heart tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human brain tissue, human brain tissue, human heart tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
A kinase (PRKA) anchor protein 7

Calculated molecular weight:
81aa,9 kDa

Observed molecular weight:
11 kDa,18 kDa,37 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AKAP7

Synonyms
A kinase anchor protein 18 kDa, AKAP 18, AKAP 7 isoforms alpha and beta, AKAP18, AKAP7
Background

AKAP7, also named as AKAP15 and AKAP18, localize PKA in complexes with CaV1.2 and PLN, respectively. AKAP7 targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. AKAP7 has short isoform AKAP7 alpha and AKAP7 beta with MW 15-18 kDa; long isoform AKAP7 gamma with MW 37-42 kDa. AKAP7alpha was highly expressed only in brain and weakly in lung lysates from WT animals. This antibody can recognize all the isoforms of AKAP7.


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