ALDH1L2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21391-1-AP

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Freight/Packing

Con: 68 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse kidney tissue, HEK-293 cells, mouse kidney tissue

Positive IHC detected in:
human pancreas tissue, human heart tissue, human pancreas tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
aldehyde dehydrogenase 1 family, member L2

Calculated molecular weight:
923aa,102 kDa

Observed molecular weight:
102 kDa, 89 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALDH1L2

Synonyms
ALDH1L2, DKFZp686A16126, DKFZp686M064, FLJ38508
Background

ALDH1L2(Aldehyde dehydrogenase family 1 member L2) is also named as mitochondrial 10-FTHFDH, mtFDH and belongs to the aldehyde dehydrogenase family and ALDH1L subfamily. The ALDH1L2 gene has three transcriptional variants with the molecular weight of 102 kDa, 42 kDa and 89 kDa(PMID:19823103). It is a mitochondrial enzyme, a likely source of CO2 production from 10-formyltetrahydrofolate in mitochondria and playing an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell(PMID: 20498374). It also has dehydrogenase/hydrolase activities similar to cytosolic FDH (ALDH1L1). The native ALDH1L2 has been reported to exist as a dimer or tetramer(PMID:7822273).


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