ALK,CD246 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 24184-1-AP

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Con: 50 μg/150 μl

Choose size:

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Species specificity:

Positive IHC detected in:
human lymphoma tissue, human brain tissue, human lymphoma tissue

Recommended dilution:
IHC : 1:20-1:200

Product Information


Purification method:
Antigen Affinity purified


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
anaplastic lymphoma receptor tyrosine kinase

Calculated molecular weight:
1620aa,176 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol

ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, TFG/ALK

ALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).

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