TEM8 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15091-1-AP

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Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse testis tissue, HeLa cells, mouse lung tissue, PC-13 cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
anthrax toxin receptor 1

Calculated molecular weight:
63 kDa

Observed molecular weight:
85 kDa,80 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ANTXR1

Synonyms
anthrax toxin receptor 1, ANTXR1, ATR, FLJ10601, FLJ11298, FLJ21776, TEM8, Tumor endothelial marker 8
Background

Tumor endothelial marker 8 (TEM8, ANTXR1) and capillary morphogenesis protein 2 (CMG2, ANTXR2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding (PMID: 23271637). TEM8 is a highly-conserved single-pass cell-surface protein overexpressed on tumor-infiltrating vasculature, and is thought to play a positive role in endothelial cell activities related to angiogenesis (PMID: 11559528; 15777794 ). The long isoforms of TEM8 have been identified as an 80-85 kDa doublet, and experimental deglycosylation reduced the molecular mass to 70 kDa, indicating that TEM8 undergoes multiple glycosylations (PMID: 14871805; 15689409).


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