APOB Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 20578-1-AP

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Con: 27 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse liver tissue, HEK-293 cells, HepG2 cells, L02 cells

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
apolipoprotein B (including Ag(x) antigen)

Calculated molecular weight:
516 kDa

Observed molecular weight:
130-150 kDa, 200-250 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
APOB

Synonyms
Apo B 100, Apo B 48, APOB, ApoB100, Apolipoprotein B, Apolipoprotein B 100, FLDB
Background

The apolipoprotein B (ApoB) is a plasma protein synthesized primarily in the liver and intestine and play an important role in lipid and cholesterol metabolism. The ApoB gene encodes two different isoproteins through mRNA editing, ApoB-48 and ApoB-100. ApoB-100 is synthesized exclusively by the liver and is essential for the assembly of VLDL in the liver. ApoB-48 is synthesized exclusively by the small intestine and is essential for the assembly of chylomicrons in the intestine. ApoB-48 and ApoB-100 share a common N-terminal sequence, but ApoB-48 lacks ApoB-100's C-terminal LDL receptor binding region. It is well established that ApoB-100 levels are associated with coronary heart disease. This antibody recognizes both of ApoB-48 and ApoB-100.


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