APOL1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 11486-2-AP

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Freight/Packing

Con: 66 μg/150 μl

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Species specificity:
human, mouse, zebrafish

Positive WB detected in:
human blood tissue, A2780 cells, A549 cells, HeLa cells, HepG2 cells, MCF-7 cells, SKOV-3 cells, SW 1990 cells

Positive IP detected in:
HepG2 cells, human plasma tissue

Positive IHC detected in:
human kidney tissue, human kidney tissue, human liver tissue, human pancreas tissue, human spleen tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
apolipoprotein L, 1

Calculated molecular weight:
44 kDa

Observed molecular weight:
39 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
APOL1

Synonyms
APO L, APOL, APOL I, APOL1, Apolipoprotein L, Apolipoprotein L I, apolipoprotein L, 1, Apolipoprotein L1
Background

Human apolipo-protein L1 (APOL1) is a minor component of plasma high density lipoprotein (HDL) particles, acting as an interacting protein of apolipoprotein A1 (ApoA1). The human ApoL protein family was thought to be predominantly involved in lipid transport and metabolism. APOL1 is also involved in host innate immunity against Trypanosoma parasites. Once activated, APOL1 can lyse the parasite and protect human from infection. Genetic variants in APOL1 gene, which are found in African ancestry with high frequency, associate with chronic kidney disease, like focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. APOL1 share structural and functional similarities with proteins of the Bcl-2 family and may has roles in apoptosis and autophagy. It is notable that APOL1 exists only in human and a few other primate species, and mouse does not express an APOL1 orthologue. This antibody recognizes the endogenous APOL1 of 39-45 kDa in blood lysate.


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