ARG1 Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 16001-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, human colon tissue, human heart tissue, human liver tissue, mouse heart tissue

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human liver cancer tissue, human heart tissue, human kidney tissue, human liver tissue, human liver cancer tissue, human lung tissue, human placenta tissue, human spleen tissue, human testis tissue, mouse kidney tissue, mouse liver tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
arginase, liver

Calculated molecular weight:
236aa,25 kDa;322aa,35 kDa

Observed molecular weight:
35-36 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ARG1

Synonyms
ARG1, Arginase 1, liver Arginase, Liver type arginase
Background

Arginase-1 (Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protect motor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539). It can exist as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing. Defects in ARG1 are the cause of argininemia (ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406). ARG1 has 3 isoforms with the molecular mass of 25, 35 and 36 kDa.


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