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CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis.
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BMAL1, a basic helix–loop–helices with Per–Arnt–Sim (PAS) domain transcription factor, is one of components that has core clock function in mammals. It form a heterodimer with CLOCK, and induce the transcription of target genes by binding to E-box elements within their promoter regions. And this transcription is inhibited in a feedback loop by PER, and also by CRY proteins.Also BMAL1 is a key player in the regulation of metabolism, playing a role in adipogenesis and in the control of glucose and triglycerides levels.