ARPP-19 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11678-1-AP

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Freight/Packing

Con: 76 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, A375 cells, A549 cells, mouse brain tissue, rat skeletal muscle tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human gliomas tissue

Positive IF detected in:
A375 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cyclic AMP phosphoprotein, 19 kD

Calculated molecular weight:
19 kDa

Observed molecular weight:
19 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ARPP-19

Synonyms
ARPP 16, ARPP 19, ARPP16, ARPP19, ARPP-19, FLJ41622
Background

ARPP-19, a 19-kDa cAMP-regulated phosphoprotein, plays a role in regulating mitosis. Initiation and maintenance of mitosis require the activation of protein kinase cyclin B–Cdc2 and the inhibition of protein phosphatase 2A (PP2A). When phosphorylated by protein kinase Greatwall (Gwl), ARPP-19 associate with and inhibit PP2A, thus promoting mitotic entry. ARPP-19 may be an important link between nerve growth factor (NGF) signaling and post-transcriptional control of neuronal gene expression such as GAP-43.


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