ATP1A2 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 16836-1-AP

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Con: 31 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells

Positive IHC detected in:
human skin tissue, human brain tissue, human heart tissue, human kidney tissue, human liver tissue, human testis tissue

Positive IF detected in:
Hela cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2400
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide

Calculated molecular weight:
1020aa,112 kDa

Observed molecular weight:
97-100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATP1A2

Synonyms
alpha 2 ATPase, ATP1A2, FHM2, KIAA0778, MHP2, Sodium pump subunit alpha 2
Background

ATP1A2 (Na+/K+-ATPase α-2 subunit) is the catalytic component of the active enzyme Na+/K+-ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. The Na+/K+-ATPase is composed of a larger catalytic α-subunit (~110 kDa) and a small β-subunit (~55 kDa). The α subunit has four isoforms identified to date: α1, α2, α3 and α4.The α1 isoform is expressed ubiquitously but the α2 isoform is present largely in the skeletal muscle, heart and vascular smooth muscle. The α3 isoform is found almost exclusively in neurons and ovaries. The α4 isoform is expressed in sperm. This antibody was raised against the internal region of the human ATP1A2 and can recognizes all the isoforms of α subunit. The 65kDa band detected occasionally may be the degradation product of ATP1A2.


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