ATPIF1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12067-1-AP

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells

Positive IP detected in:
HeLa cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ATPase inhibitory factor 1

Calculated molecular weight:
106aa,12 kDa

Observed molecular weight:
12 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATPIF1

Synonyms
ATPase inhibitory factor 1, ATPI, ATPIF1, ATPIP, IF(1), IF1, Inhibitor of F(1)F(o) ATPase, IP
Background

The H(+)-ATP synthase is a reversible engine of mitochondria that synthesizes or hydrolyzes ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and progression of diverse human pathologies. ATPIF1 gene encodes mitochondrial ATPase Inhibitory Factor 1 (IF1), also named ATPI, ATPIP or IP. Endogenous IF1 limits ATP depletion when the mitochondrial membrane potential falls below a threshold and the ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Mitochondrial content of IF1 controls the activity of oxidative phosphorylation mediating the shift of cancer cells to an enhanced aerobic glycolysis, thus supporting an oncogenic role of IF1 in cancer.


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