BACE1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 12807-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 28 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, zebrafish, rat

Positive WB detected in:
mouse brain tissue, HeLa cells, human brain tissue, mouse brain tissue, mouse pancreas tissue, zebrafish tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
mouse brain tissue, human pancreas cancer tissue, mouse brain tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
beta-site APP-cleaving enzyme 1

Calculated molecular weight:
501aa,56 kDa

Observed molecular weight:
70-75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BACE1

Synonyms
Asp 2, ASP2, Aspartyl protease 2, BACE, BACE1, Beta secretase 1, FLJ90568, HSPC104, KIAA1149, Memapsin 2
Background

beta-secretase, encoded by BACE1(beta-stie amyloid beta A4 precursor protein-cleavage enzyem1) gene, is a neuron-specific membrane-associated protease that participate in the two step proteolytic processing of the APP. Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has a high expression in the brain and pancreas. This protein has 6 isoforms produced by alternative splicing. BACE1 can be detected with different molecular weight: 42-56kD (prozymogen and isoforms), 65-75 (glycosylated forms) and 160kDa (dimer) (PMID:22741101; 21795680).


Back
to top