BAK Polyclonal antibody

BAK Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 14673-1-AP

Synonyms

Apoptosis regulator BAK, BAK, BAK LIKE, BAK1, CDN1



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

14673-1-AP targets BAK in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat, sheep
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen BAK fusion protein Ag6354
Full Name BCL2-antagonist/killer 1
Calculated molecular weight 23 kDa
GenBank accession numberBC004431
Gene symbol BAK1
Gene ID (NCBI) 578
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

BAK1, also named as BAK, BCL2L7 and CDN1, belongs to the Bcl-2 family. In the presence of an appropriate stimulus, BAK1 accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. (PMID:17157251) BAK1 gene product primarily enhances apoptotic cell death following an appropriate stimulus. It can inhibit cell death in an Epstein-Barr virus-transformed cell line.

Publications

SpeciesApplicationTitle
ratWB

Biomed Pharmacother

HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.

Authors - Xuemei Sun
humanWB

Target Oncol

Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.

Authors - Fangbing Liu
mouseWB

Toxicol Appl Pharmacol

PMID: 30342059

Authors - Xiangrong Geng
humanWB

Genes Cancer

Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.

Authors - Qianwen Zhang
ratWB

Transplantation

Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.

Authors - Xufeng Tao
humanWB

Mol Med Rep

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.

Authors - Huiling Jing