BAK Antibody

BAK Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 14673-1-AP

Synonyms

Apoptosis regulator BAK, BAK, BAK LIKE, BAK1, CDN1



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

14673-1-AP targets BAK in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat, sheep
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen BAK fusion protein Ag6354
Full Name BCL2-antagonist/killer 1
Calculated molecular weight 23 kDa
Observed molecular weight
GenBank accession number BC004431
Gene symbol BAK1
Gene ID (NCBI) 578
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

BAK1, also named as BAK, BCL2L7 and CDN1, belongs to the Bcl-2 family. In the presence of an appropriate stimulus, BAK1 accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. (PMID:17157251) BAK1 gene product primarily enhances apoptotic cell death following an appropriate stimulus. It can inhibit cell death in an Epstein-Barr virus-transformed cell line.

Publications

SpeciesApplicationTitle
ratWB

Biomed Pharmacother

HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.

Authors - Xuemei Sun
humanWB

Target Oncol

Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.

Authors - Fangbing Liu
mouseWB

Toxicol Appl Pharmacol

Role of ZIP8 in regulation of cisplatin sensitivity through Bcl-2.

Authors - Xiangrong Geng
humanWB

Genes Cancer

Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.

Authors - Qianwen Zhang
ratWB

Transplantation

Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.

Authors - Xufeng Tao
humanWB

Mol Med Rep

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.

Authors - Huiling Jing