BCCIP Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 16043-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, A549 cells

Positive IP detected in:
HeLa cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BRCA2 and CDKN1A interacting protein

Calculated molecular weight:
314aa,36 kDa

Observed molecular weight:
50-58 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCCIP

Synonyms
BCCIP, Protein TOK 1, TOK 1, TOK1
Background

BCCIP (or TOK1) is isolated as a BRCA2- and CDKN1A (p21)-interacting protein and is implicated in homologous recombination (HR) pathway and inhibition of DNA replication stress. BCCIP is an evolutionarily conserved nuclear protein with multiple interacting domains. BCCIP deficiency in mice impaired embryonic and postnatal neural development, causing severe ataxia, cerebral and cerebellar defects, and microcephaly, which are associated with spontaneous DNA damage and subsequent cell death in the proliferative cell populations of the neural system during embryogenesis. BCCIP is essential for maintaining the transactivation activity of wild type p53 suggesting a potential role of BCCIP in cancer etiology.


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